Oral and Nasal Care
Background Of The Enzyme Application In Oral and Nasal Care
Since 2006, Botai Biotechnology was founded by Dr. Meng, a Harvard postdoctoral scholar. After returning from the United States, he brought top academic achievements in enzymology to China and established the company.
We have formed an elite R&D team of over ten experts, focusing on the extraction, development and application of Mn-SOD manganese superoxide dismutase. Our core research is to sustain its high activity and high purity in practical use.
Most antioxidant enzymes on the market lose activity during application, failing to deliver real benefits against free radicals to the human body.
Our high-activity SOD effectively fades skin pigmentation and dark spots. It also relieves chronic inflammation in the digestive system, repairs respiratory mucosal damage, and improves various sub-health problems and chronic inflammations caused by weakened antioxidant capacity in organs.
The Relationship Between Free Radicals and Antioxidant Enzymes
Free radicals have long been a hot research topic in life sciences. Reactive Oxygen Species (ROS) are the most common free radicals in the human body, mainly existing in the form of oxygen free radicals.
Excess ROS causes lipid peroxidation, damages the structure and function of biofilms, leads to protein denaturation, cross-linking and enzyme inactivation. It is closely associated with myocardial shock, radiation injury, atherosclerosis, immune deficiency and many other diseases.
Excessive free radicals trigger oxidative reactions, damage human tissues and cells, and accelerate aging — this is the well-known free radical aging theory proposed by Harman.
Oxidative stress induces oxidative damage to biomolecules, produces endogenous Damage-Associated Molecular Patterns (DAMPs) and releases cytokines. These activate downstream signaling pathways such as NF-κB, JAK, STAT and MAPK, further releasing cytokines and chemokines, recruiting inflammatory cells and causing systemic chronic inflammation.
Based on the link among oxidative stress, inflammation and aging, scholars put forward the oxidative-inflammatory aging theory, confirming that oxidative stress is a key driver of inflammatory aging.
Superoxide Dismutase (SOD) is widely present in organisms. As an indispensable oxygen free radical scavenger, it plays a vital role in defending against oxidative damage.
According to bound metal ions, SOD is divided into four types: Cu/Zn-SOD, Fe-SOD, Mn-SOD and Ni-SOD. Researches prove that SOD effectively eliminates oxygen free radicals, relieves various inflammations and protects against radiation damage. Among them, Mn-SOD features the highest stability and lowest toxicity.
In the mitochondrial oxidative phosphorylation electron transport system, oxygen is the final electron acceptor. When electron transfer is incomplete, high-activity ROS is generated. ROS attacks lipids, proteins and DNA, triggering neurodegeneration, aging, cancer, pulmonary fibrosis and vascular diseases, and it is also a key inducer of inflammation.
Inflammation is the body’s defense against infection, trauma and ischemia. Abnormal inflammatory responses cause multiple diseases, with leukocyte migration and infiltration as typical pathological features.
Antioxidant enzymes are core regulators of inflammation. Mitochondrial Mn-SOD is the first line of defense against oxygen free radicals; its activity directly determines free radical scavenging efficiency and inflammation repair effect.
In mammals, Mn-SOD is located in mitochondria, regulating oxygen balance and protecting mitochondria from free radical damage. Studies show Mn-SOD is closely related to inflammation and cellular senescence.
Mn-SOD gene deficiency leads to severe mitochondrial damage and even fetal death, while Mn-SOD supplementation can significantly prolong survival.
Mn-SOD is expected to become a new natural anti-inflammatory and anti-aging ingredient for health care.
Oral and nasal care is one of the applicable fields.But not limited
It also works for inflammations induced by exogenous irritants, including those triggered by biological factors, physical factors, exogenous chemical factors, or their combined effects.
Inflammations caused by biological factors refer to tissue irritation and lesions resulted from bacteria, viruses, rickettsiae, protozoa, fungi, spirochetes and parasites.
As for inflammations triggered by exogenous chemical factors, it improves adverse reactions stimulated by radioactive substances, strong acid, strong base, strong oxidants, alcohol and chemical drugs. It is especially suitable for alleviating alcoholic or drug-induced hepatitis and inflammation formed after chemotherapy.
In addition, the product is effective for common skin inflammation problems, such as tinea manus and pedis, folliculitis, contact dermatitis, eczema, urticaria, neurodermatitis and seborrheic dermatitis, and is also friendly for relieving infant eczema.
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We are one of the most professional oral and nasal care manufacturers and suppliers in China. With a professional production team, we are able to meet the needs of the majority of our customers. Welcome to wholesale custom made oral and nasal care from our factory.